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In the realm of hematological malignancies, an intriguing combination of venetoclax with either decitabine or azacitidine was tested on elderly acute myeloid leukemia (AML) patients who were deemed unfit for conventional chemotherapy

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This supports the formation of paracrine positive feedback loops, which in turn can support the dissemination of cancer cells to distant locations

Therefore, ER+ cancer models showed heterogenous sensitivity to depletion of GPX4, but with consistent sensitisation to CDK4/6 inhibition by GPX4 depletion