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The ideal responder profile, while biologically coherent, was identified through post hoc subgroup exploration and is vulnerable to overfitting and multiple comparison artefacts

Certainly, long-lasting HPV infection and the resulting abnormalities in the cervix not only cause considerable physical distress but also place substantial psychological and economic strain on affected individuals

Headaches occur occasionally but are generally mild and respond to standard over-the-counter analgesics

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Genetic predisposition can modulate cellular sensitivity to apoptosis, and multiple regulatory factors are involved, including inflammatory mediators (IFN-, IL-2, IL-1), TSH, and anti-TPO antibodies