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Gastrointestinal AEs were the most frequently observed AEs, consistent with previous findings [5, 10,11,12,13,14,15,16,17,18]

The GLP-1 and dual/triple-agonist compounds (Semaglutide, Tirzepatide, Retatrutide) have substantial registered human-trial data

Evidence Quality Gap The most important dimension of this comparison is the quality and scale of the clinical evidence

doi: 10.1016/S2213-8587(19)30412-7 164 GreenAHedeSMPattersonCCWildSHImperatoreGRoglicGet al

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