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mitochondrial glutathione reductase SMPDB Controlling glutathione entry into mitochondria:
Description
doi: 10.1152/jn.1999.82.5.2776 [DOI] [PubMed] [Google Scholar] 47
doi: 10.1152/ajpregu.1995.268.1.R286
usually related to rapid injection
When clearance is related to age, it is found that clearance of this drug does not change with age
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Furthermore, UNC12149 was titrated in the cell-based HiBit assay which revealed a DC 50 value of 120 nM, which is ~4-fold more potent than UNC10415667 and ~10-fold more potent than the parent molecule UNC8732 (Figs