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After binding with PERK, TMAO selectively activates PERK-mediated UPR, thereby promoting metabolic dysfunction ( Of note, TMAO in the pathogenesis of Alzheimers disease (AD) indicated that PERK is not the only mechanism by which TMAO induces UPR

Mediating effects of aryl-hydrocarbon receptor and RhoA in altering brain vascular integrity: The therapeutic potential of statins

Biochimie 96 , 113120 (2014)

A major route of action is controlling fatty acid metabolism, as previously mentioned

developed a metabolomics fingerprinting method using CE coupled to an electrospray ionization-time of flight-mass spectrometer (CE-TOF-MS) (Naz et al., 2013)

Therefore, changes in fatigue and S-5-HT levels were examined with Related-Samples Wilcoxon Signed Rank Test within-subjects (before vs