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Therefore, despite coppers promoting effects on cell survival and proliferation, and the dependence of tumor cells on copper, inducing copper accumulation in cancer cells can specifically induce the production of higher levels of ROS in tumor tissues based on the sensitivity of cancer cells to ROS and the higher concentration of copper ions in cancer tissues

Collectively, these findings underscore a pathogenic synergy wherein -syn aggregation and lipid peroxidation co-amplify each other, culminating in ferroptotic cell death and neurotoxicity

Alzheimers Dement, 2021

Alebic-Juretic A, Frkovic A

PEG-Fns, Polyethylene glycol (PEG)-coated ferrihydrite nanoparticles

Many clinical studies fail to incorporate longitudinal assessments of both microbiome and neurocognitive data