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Stephenson CM, Levin RD, Spector T, Lis CG (2013) Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer

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Another study from Japan found similar results with ultra-high doses, with no adverse effects

Type XV collagen Type XV collagen is expressed in various tissues, muscle cells, fibroblasts and ECs and is in the basement membrane of vessels 103,104

doi: 10.1182/blood.V92.4.1191 41

Zinc deficiency may be part of why thinning hair 36 is a common symptom of hypothyroidism