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Instability of the naked miRNA The inherent instability of miRNA in blood is a barrier to miRNA-based treatment

All viral glycoproteins share the characteristic of their assembly into oligomers that necessitates the formation of a disulfide bond and this is inhibited by the reducing action of GSH

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Contamination can arise from worn machinery parts (such as bearings or cutting blades) or damaged sieves that shed shards during the mixing, grinding and packaging phases

Proper storage is critical