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Parallel research on NAD biology (e.g., precursors like NR/NMN) reinforces the centrality of NAD to mitochondrial output and recoverymechanistically aligned with 5-Amino-1MQs NNMT inhibition (Cant et al., Cell Metabolism )

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Doses above 100mg daily show diminishing returns in NNMT inhibition the enzyme inhibition curve plateaus beyond 150mg while increasing the risk of methylation pathway disruption and homocysteine elevation

Men who stop taking AAS may experience decreased libido, erectile dysfunction, fatigue, and depression symptoms (Kanayama et al., 2015