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While certain foods, such as avocados, asparagus, and broccoli, contain small amounts of glutathione precursors, supplementation is often necessary to achieve optimal levels.

The currently widely accepted theories of MDD pathogenesis include the neurotransmitter and receptor hypothesis, hypothalamic-pituitary-adrenal (HPA) axis hypothesis, cytokine hypothesis, neuroplasticity hypothesis and systemic influence hypothesis, but these hypothesis cannot completely explain the pathological mechanism of MDD

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