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In the embryo, thyroid hormone is necessary for normal development and hypothyroidism in the embryo is responsible for cretinism, which is characterized by multiple congenital defects and intellectual impairment

In addition, small sample sizes (e.g., some studies included fewer than 30 cases) may reduce statistical power and hamper the ability to effectively detect differences between patients and healthy controls

Jun 2020;79(6):829-836

[DOI] [PubMed] [Google Scholar] 34.Sims N

High-dose methionine supplementation has theoretical concerns regarding homocysteine elevation, though this is unlikely at typical lipotropic injection doses