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doi: 10.1016/j.nbd.2011.12.015

Rubbi, L

Preclinical Safety Evaluation In preclinical studies, BPC 157 did not lead to any serious toxicity in tested animals, including: mice rats rabbits dogs These studies provide a strong foundation for understanding the safety profile of BPC 157, indicating that it is well-tolerated across different species

However, PAI-1 carbonylation has been demonstrated to influence its functional activity and structural stability [38], therefore carbonylated PAI-1 may exhibit reduced activity, and we hypothesize that it could trigger a compensatory mechanism leading to an increase in its overall concentration observed in our cohort

10.1186/s12974-019-1653-7 180 Liu-AmbroseT.NagamatsuL

Perfusate proteomes provide biological insight into oxygenated versus standard hypothermic machine perfusion in kidney transplantation