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This indicates that the brain's antioxidant defenses begin failing long before clinical symptoms appear, offering a potential window for early intervention

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Both above studies suggest that MTHFR polymorphisms might enhance the environmental risks (low folate intake, traumatic stress at childhood) for MDD via the interaction between genetic and environmental factors

doi: 10.1016/j.chom.2020.03.011 18 ChevilleN

Eating foods and supplements rich in antioxidants are also the way to go

however, they vary in frequency and degree