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Probable reasons for such failures are the complexity of metabolic pathways, crosstalk among complex signaling pathways, and the potential systemic toxicity of metabolic drugs, as both cancer and normal cells depend on these metabolic pathways for energy production

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Li D, Xu L, Pang S, Liu Z, Wang K, Wang C (2017) Variable levels of glutathione S-transferases are responsible for the differential tolerance to metolachlor between maize ( Zea mays ) shoots and roots

doi: 10.1172/JCI116842

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