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This, in turn, boosts metabolic rate and activates a gene known as sirtuin-1 (SIRT1), also referred to as the "longevity gene." SIRT1 is involved in reducing the risk of various conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.

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Sirtuin control of mitochondrial dysfunction, oxidative stress, and inflammation in chagas disease models

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Interestingly, Tf-functionalized NPs were used to transport siRNA against human P-gp/ABCB1 (P-gp/ABCB1-siRNA) specifically to the BBB, resulting in temporary reduction in drug efflux and enhanced drug permeability in the CNS