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doi: 10.1371/journal.pbio.3000604 135 ZhangTTangYYangXWangXDingSHuangKet al

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Mutations in the Parkin Gene Cause Autosomal Recessive Juvenile Parkinsonism
The loss of GPX4, an essential enzyme that shields cells from LP, would make neurons more vulnerable to ferroptosis (Bellinger et al., 2011
DSIP, Delta Sleep-Inducing Peptide, is a naturally occurring neuropeptide first isolated in 1977

While the pro-inflammatory effect of microcrystalline UA is well-established 3,20 , there are several indications that soluble UA free of UA crystals has protective effects against inflammatory mechanisms and toxicity 50 with effects on macrophage polarisation towards the anti-inflammatory M2 phenotype 51
