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Interestingly, drug sensitivity in those cell lines was not due to either difference on DNA repair capacity, or in the amount of membrane ion channel commonly used for cisplatin uptake

Figure 4 The paradigm shift occurring in the field of DNA replication may extend to cell division

DEGs significantly ( p -value 0.05) upregulated with a log 2 FC 0.5 or downregulated with a log 2 FC 0.5 in any of the sequenced samples were selected for further analysis

All libraries were sequenced with an 8-base index read, a 26-base read 1 containing cell-identifying barcodes and unique molecular identifiers (UMIs), and a 98-base read 2 containing transcript sequences on an Illumina HiSeq 4000 instrument

It has been proposed that GLP-1 agonists may hinder lipase secretion in the intestinal lumen, thereby slowing gastric emptying and inhibiting fat absorption [107]