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Background: The prevalence of Parkinson's disease (PD) is increasing, with approximately 135,000 patients reported in Japan

Shah R, Shchepinov MS, Pratt DA

Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle

therefore, additional neuronal systems are likely involved

Heme oxygenase is expressed primarily in the macrophages of the reticuloendothelial system (RES) (spleen, liver, and bone marrow), but is induced under conditions of stress in many if not all cells (75)
