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Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity

In addition, it has been reported that NAFLD can promote the formation of AGEs, which, on the one hand, may be associated with oxidative stress and the production of inflammatory compounds

doi: 10.1016/j.jprot.2018.06.009

Lipid peroxidation generates hydroperoxides as well as endoperoxides, which undergo fragmentation to produce a broad range of reactive intermediates called reactive carbonyl species (RCS) (Figure 4) with three to nine carbons in length, the most reactive being ,-unsaturated aldehydes [4-hydroxy-trans-2-nonenal (HNE) and acrolein], di-aldehydes [malondialdehyde (MDA) and glyoxal], and keto-aldehydes [4-oxo-trans-2-nonenal (ONE) and isoketals] [24]

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TCE also disrupts cardiogenesis in human embryonic stem cells (94)