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From the study of new phenyl dihydrouracil (PD)-based PROTACs designed by this group, PD-PROTAC 113 (SJ43489) stands out, capable of degrading the LCK protein (DC 50 = 0.8 nM) and inhibiting the cell viability of KOPT-K1 cells with nanomolar potency (IC 50 = 37 nM) 156

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PMID: 34982483 Hum CellLong noncoding RNA SNHG3 promotes malignant phenotypes in cervical cancer cells via association with YAP1