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This deficiency can be caused by a number of factors, including: An autoimmune disorder that affects the stomach's ability to produce intrinsic factor A genetic flaw that interferes with the body's ability to transport vitamin B12 from the intestine to the bloodstream A low-vitamin B12 diet, like a vegetarian or vegan one Gastrointestinal surgery that involves the removal of a portion of the small intestine or stomach Certain medications that interfere with the absorption of vitamin B12 How does pernicious anemia affect my body

Age As people age, their ability to metabolize alcohol decreases

Dosage Protocols Used in Research Everything in this section is strictly for educational context

COEs: carboxylesterases

History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy