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This complex inhibits calcineurin, preventing the dephosphorylation and activation of the nuclear factor of activated T cells (NF-AT), which plays a crucial role in inflammatory reactions (Figure 6) [35,38,39]

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We also showed that Rv1127c was essential for Mtb growth in media containing cholesterol, or its breakdown product propionate, even in the presence of an additional growth-permissive carbon source (Basu et al, 2018)