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GEMMS involve targeted modifications of the murine genome, such as gene knockout (deletion), knock-in (mutagenesis), or transgenic overexpression, enabling the study of tumor biology within an intact immune system and native tissue microenvironment

5, the characteristic absorption peak at 584 nm for both M-CuP and D-CuP exhibited no statistically significant variation across the tested pH range

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By contrast, inhibitors of PI3K/AKT (LY294002), p38 MAPK (SB203580), or ERK1/2 (U0126) do not hinder the LPP-induced production of aggrecan, collagen II, and Sox9