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2020 May;59(5):512-519

Foster, D

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The monomer also impairs retinal pigment epithelium functionality by elevating paracellular permeability and disrupting the tight junction proteins ZO-1 and occludin, while another study found that mCRP upregulates IL-8 and CCL2 gene expression and protein secretion, and also binds to complement factor H, which dampens its proinflammatory activity in these cells while increasing phagocytosis [110,111]

In: Adam M.P., Feldman J., Mirzaa G.M., Pagon R.A., Wallace S.E., Amemiya A., editors