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PubMed Liu T, et al

Further, the combined use of Sph_12-38 and SHS resulted in a cure rate of 100% for rabbit ear acne treatment in vivo for two weeks, while the one induced by other groups was 40%, 0% and 0% for SHS alone, Sph_12-38 alone and control group, respectively

Standard protocols use once-daily administration for 714 days during the induction phase, with some studies employing twice-daily dosing in the first week to maximize early receptor activation

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PMID: 41901308