dr marcus laux glutathione Comprehensive blood metabolomics profiling of Parkinson's disease reveals coordinated alterations in xanthine metabolism IJMS | Topical Collection :

SIRT6 alleviates mitochondrial dysfunction, podocyte injury, and ferroptosis induced by HG through activating the Nrf2/GPX4 pathway and increasing SLC7A11, HO-1, and SOD2 expressions

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Hence, further prospective studies addressing the incidence of DPN in relation to the degree of vitamin B12 deficiency per daily and cumulative doses of metformin in each therapeutic period are necessary to clarify the complex relationship between metformin treatment, vitamin B12 deficiency, and DPN occurrence in T2D (173) ( Box 3 )

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The significance was set at BH-FDR corrected p value 1.5, and p values 0.05)