glutathione reductase ascorbate What Are the Roles for Dehydroascorbate Reductases and in Sustaining Accumulation? Glutathione-ascorbate cycle - Wikipedia
Description
Alcohol Drug Res

B12 is also involved in many of these processes, but it works alongside folate as a coenzyme in these processes: both vitamins are required for normal function

B.TerentievA

C., Heydon, E

For instance, healthy liver function requires a number of things like glutathione to detox naturally and cope with the stress and inflammation from toxins
It could be that reduced neural signaling within posterior brain areas leads to lower regional GSH levels