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ACKNOWLEDGMENTS The authors thank patients, and their families as well as F Breedveld, A Rabelink, L Aarts, E Lansink and E Sarton for support and assistance in making this study possible

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The effect of load levels and time-points were studied using a two-way ANOVA with the data from early healing (1-, 2- and 3-weeks post injury) followed by Tukeys post hoc analysis for multiple comparisons for load differences at each time-point

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IUPHAR reviewglucagon-like peptide-1 (GLP-1) and substance use disorders: an emerging pharmacotherapeutic target