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Further, the periodic introduction of decreased maintenance doses during 2-3 months or for life is possible

However, this initial inflammatory response may lead to the development and progression of CKD which results from the involvement of activated effector cytotoxic CD8+ T cells (Tc cells) and helper CD4+ T cells (Th cells), mast cells, natural killer (NK) cells as well as macrophages/monocytes and dendritic cells (9, 10)

Although the magnitude of the effects were modest, the supplement group reported roughly twice the improvement as did the placebo group on the Average Change score (the average of all the PGI-R scores)