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Tumor dimensions (length and width) and body weight were measured using a caliper every two days, and tumor volumes were calculated using the following formula: At the end of the experiment, the mice were euthanized, and whole blood, heart, liver, spleen, lungs, kidneys, tumor-draining lymph nodes (TDLNs), and tumors were harvested for imaging and weighing

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For each study, the subject/species, experimental design and altitude exposure, key microbial changes (with directional shifts indicated by /), associated metabolites, functional role in adaptation, and corresponding references are provided