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This direct scavenging neutralizes unstable radicals such as superoxide, hydroxyl radicals, and lipid peroxyl radicals before they can tear through the cellular membrane

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TGF- is an important regulator of neovascularization in tumor and it acts in a context-dependent manner by promoting angiogenesis via stimulation of pro-angiogenic factors like VEGF or inhibiting tumor angiogenesis by impairing endothelial cell proliferation and migration or by inducing apoptosis [211]