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It can result in drugs being cleared from the system faster, potentially reducing the drug's effectiveness. On the other hand, some natural products can inhibit these important drug-metabolising enzymes, resulting in reduced clearance of the drug and therefore increased exposure to it

Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctions in diet-induced obese mice

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By clarifying the mechanistic basis of curcumins neuroprotective effects and assessing its translational potential, this review aims to provide a balanced overview of both the opportunities and limitations of curcumin-based interventions in neurodegenerative diseases

doi: 10.1016/j.phrs.2021.105465 61 ChuLValenciaIJGarvertDWMontoyaJG

The text was also updated in Section 5, Warnings and Precautions (Subsections 5.2, Structural Birth Defects, 5.3, Decreased IQ and Neurodevelopmental Disorders Following in utero Exposure, 5.4, Use in Women of Childbearing Potential, 5.13 Serious Dermatologic Reactions, 5.14, Angioedema), Section 6, Adverse Reactions, Subsections 7.1, Effects of Co-Administered Drugs on Valproate Clearance, 7.4, Cannabidiol, 8.1, Pregnancy, and Section 17, Patient Counseling Information