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Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits

10.1016/j.thromres.2011.07.035 [DOI] [PubMed] [Google Scholar] Stupnisek M., Kokot A., Drmic D., Hrelec Patrlj M., Zenko Sever A., Kolenc D., et al

D., Sirbescu, M.-L.C., Marques, J

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Any reference to biological activity or potential effects is based solely on preclinical or in-vitro findings and should not be interpreted as validated clinical outcomes

Sometimes a hip injection may be needed