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13 Journal of Medicinal Chemistry (ACS)Bisubstrate inhibitors of NNMT with enhanced activity

5-Amino-1MQ for Diabetes and Metabolic Disorders NNMT is a potential biomarker for reduced insulin sensitivity, since higher activity of this enzyme has been linked to insulin resistance and type 2 diabetes [9]

GHK-Cu, or glycyl-L-histidyl-L-lysine copper, is a naturally occurring tripeptide first found in human plasma

The authors interpreted the data as supporting NNMT inhibition as a candidate exercise-mimetic

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