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The MTHFR gene polymorphism is linked to onset, clinical symptoms, prevalence as well as response to treatments

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Therefore, it is reasonable using supplementation of liposomal glutathione, instead of the N-acetylcysteine or bonded cysteine utilized as precursors for GSH cell synthesis, since patients with deficient levels of glutamate-cysteine ligase and GSH synthetase will not be able to use N-acetylcysteine or bonded cysteine as substrates to synthesize their own GSH

In addition, a variety of synthetic compounds with in vitro antioxidant activity have been developed to treat diseases, including recombinant SOD, catalase, nitroxyl radicals, iron ion chelators, deuterated PUFAs, thiols, and ROS-generating enzyme inhibitors

A 2 Year Multidomain Intervention of Diet, Exercise, Cognitive Training, and Vascular Risk Monitoring Versus Control to Prevent Cognitive Decline in AtRisk Elderly People (FINGER): A Randomised Controlled Trial. Lancet 385: 22552263