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Research Evidence Evidence shape FOXO4-DRI has no human clinical evidence: zero published human studies and zero registered trials, completed, ongoing, or terminated

Pyocyanin (1-hydroxy-5-methyl-phenazine) is an electrochemically (redox) active metabolite and zwitter ion that triggers the formation of reactive oxygen species (ROS) that, in turn, induce oxidative stress and deplete intracellular antioxidant (glutathione) levels in host cells (OMalley et al., 2004)

Topoisomerase inhibition by phenolic metabolites: a potential mechanism for benzene's clastogenic effects Carcinogenesis (Oxford) 1995 16 : 23012307 Smith MT, Zhang L, Wang Y, Hayes RB, Li G, Wiemels J, Dosemeci M, Titenko-Holland N, Xi L, Kolachana P, Yin S, Rothman N

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The first drug to be evaluated was regorafenib

The results in these cases should merely serve as a motivating factor to pursue this line of research with more vigor, specifically in analyses which involve controls and determination of true statistical value