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Current evidence supports continuous use for 812 weeks followed by a 4-week washout period to assess sustained metabolic improvements and prevent receptor downregulation

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doi:10.1101/2023.11.20.567908 18

BPC 157 showed effectiveness over the NO-system background, immobilized (L-NAME + L-arginine), (over)stimulated (L-arginine) or blocked (L-NAME)

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In females, this pattern reversed after a 21-d recovery and by d35, TAM chow-fed mice weighed significantly more than vehicle chow-fed female mice (18.13 0.25 g veh chow vs 20.00 0.78 g TAM chow