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Upon activation by TGF-, this pathway involves the phosphorylation of Smad2 and Smad3, their association with Smad4, and subsequent nuclear translocation of the complex to regulate gene expression that favors M2 polarization (255)

Biomarker Assessment Before and During Treatment Before starting B12/Mic injections, a baseline serum B12 level, methylmalonic acid (MMA), and homocysteine can establish whether you have a true deficiency or marginal status

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ICC-MY cells serve as the pacemakers for the phasic, rhythmic electrical and contractile activity that is exhibited by GI smooth muscle (294, 303)

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