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Not all drugs need to reach the systemic circulation to exert their effects, for example, oral vancomycin used to treat pseudomembranous colitis

If you normally inject on Monday and want to switch to Thursday, simply wait until Thursday for your next injection after your Monday dose

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In reality, the motivations are far more nuanced

Response to treatment with GH therapy has been poor and one child treated with recombinant human IGF-I did not improve height after 1 year of treatment