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At all three time points, 20 genes were upregulated in the recombinant strain, including the lamA-D operon-coding genes of the quorum-sensing two component signal transduction system and the spx5 RNA polymerase-binding protein coding gene, which may help adaptation to acid stress

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However, the pharmacokinetic assessment and toxicological studies of spice-derived phytocompounds must be critically checked to evaluate their safety profile and to establish their potential in translational medicine

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