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An interesting pharmacological aspect of proteolytic enzymes, particularly bromelain, is their dual functionality based on when they are consumed
When bypassed via injection, or when very high concentrations are used topically over large surface areas, this regulatory mechanism is skipped
doi: 10.1042/BST20170503 402 JonesDEHollingsworthKGJakovljevicDGFattakhovaGPairmanJBlamireAMet al
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9 , R83 (2007)
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