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Derived from the stimulus described above, the activated NLRP3 inflammasome could stimulate caspase-1, which will process the pro-IL-1 and pro-IL-18 into mature IL-1 and IL-18 to induce pyroptotic cell death as inflammatory factors

Similarly, high concentrations of DEHP exposure, such as 10,000 nM, significantly increased the proliferation of T-47D breast cancer cells, activated the progesterone receptor (PR) signaling pathway, and altered hormone sensitivity, affecting breast development and pathological states (1)

In contrast to injections, topical serums are cost-effective, practical, and have a good safety profile, in addition to providing potential benefits for hair and skin support

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Thus far, the urobiome has not revealed any conclusive association with the pathogenesis or symptomatology of IC/BPS [17, 19]