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and genes overexpressed after trabectedin treatment (GSEA M5190) and upregulated in patients with poor prognosis (TCGA SARC), which could be targeted by specific inhibitors (Fig

In developed countries, ALF has an estimated annual incidence of 16 cases per 100,000 people, with a high mortality rate ranging from 30 to 90% without liver transplantation [2]

While MPHs US Food and Drug Administration (FDA) label does not contain pharmacogenomic biomarkers, a lot of research has been performed on the impact of genotype on MPH efficacy, and several biological pathways have been suggested to potentially affect MPH mechanisms through patient genotype, mostly concerning monoamine pathways [4348]

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The cytotoxicity of Ru(II)-OH, NP2, and NP4 against 143B and K7M2 cells in a 21% O 2 or 1% O 2 atmosphere was studied using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay