glutathione s transferase 1 S-transferase Sample size available. Alterations in the glutathione and

Second, the decrease in cell index is reversible

ROS has a dual character in living systems, both non-toxic and hazardous

Acknowledgements The authors wish to thank Mr

( f-g ) H4K12ac or H3K23ac chromatin immunoprecipitation in U2OS-mCherry-LacI-Fok1 cells treated with the IDH1 inhibitor ( f ) or transduced with shRNA targeting TMLHE (shTMLHE) ( g ) alone or supplemented with KG or l-carnitine (l-carn) supplementation (n = 3 technical replicates representative from 2 independent experiments)

By impeding glucose uptake and deactivating ATP production in mitochondria, the compounds deplete the parasite's energy reserves, leading to the paralysis of vital processes such as protein synthesis

Animal care and all experimental procedures were performed in accordance with the Guideline for Animal Experimentation of Nagasaki University with the approval of the Institutional Animal Care and Use Committee (permission number: 1803191437)