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The damaged proteins accumulate at points, which erupts on the skin's surface as scars, broken capillaries, wrinkles, etc

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Similarly, a number of early-onset familial AD mutations display a more aggressive disease course and a greater propensity for A to form soluble oligomeric A aggregates (Ferreira and Klein, 2011
Perrelli M-G, Pagliaro P, Penna C

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