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60 Dosages ranged from 2 g per day p.o

Plausible underlying mechanisms include binding excess lipid peroxides to the membrane, causing lethal changes in membrane permeability and ion concentrations

2016:bcr2016214434

Cells 36 , 22 (2018)

This trial, while not showing superiority of JTA-004 over placebo in the overall population, provides highly valuable insights into clinical trial design, placebo responses, and the potential need for better patient stratification in osteoarthritis research