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In the clinical conditions presented in the review, increased intestinal permeability has been demonstrated, but the central question of whether the barrier dysfunction is a primary event in the pathophysiology or a consequence of the disease is still not resolved in most diseases

The occurrence of hepatic stellate cells can activate hepatic stellate cells and further induce their proliferation, synthesize a large amount of cell matrix, and deposit in the extracellular space, ultimately causing liver fibrosis [40, 41]

The upregulation of NADPH oxidases (NOX enzymes) in tumour cells and tumor-associated macrophages (TAMs) also contributes to oxidative stress [43]

References Fukuda, K

Most peptides dissolve completely within 5-10 minutes at room temperature
