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These mechanisms are interesting on paper, but they come almost entirely from animals and cells
I think he did an episode on the bull sharks

What's changed is accessibility
Curcumin Prevents Osteoarthritis by Inhibiting the Activation of Inflammasome NLRP3
Remarkably, within six-month in 2020, the FDA granted two approvals for Tazemetostat, an EZH2 inhibitor, heralding a groundbreaking new chapter in the field of epigenetic therapeutics for oncology

In: Mandal SC, Chakraborty R, Sen S, editors