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Description
This inhibitory effect of heme on macrophage phagocytosis and chemotaxis occurs through the activation of the GTP-binding Rho family protein Cdc42 by DOCK8, a guanine nucleotide exchange factor, disrupting actin cytoskeletal dynamics (102)

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Systemic inflammatory response syndrome (SIRS): where did it come from and is it still relevant today

These findings were accompanied by a reduction in hippocampal neurodegeneration and inflammation, and in fact, an increase in hippocampal neuroplasticity

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[PubMed ID: 36467781]
