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BBB structure and physiology Anatomical structure of the BBB The existence of the BBB was first found by Paul Ehrlich and proved by Edwin Goldmann

It works by increasing BDNF (brain-derived neurotrophic factor), which plays a key role in learning, memory formation, and neuroplasticity

Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes

Healing also depends on collagen remodeling, fibroblast activity, vascular signaling, inflammation control, progressive loading, adequate protein intake, sleep, and correction of the movement pattern that caused the injury